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FLASH GENE
Symbol PCDH7 contributors: mct - updated : 21-04-2020
HGNC name protocadherin 7
HGNC id 8659
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • seven extracellular cadherin repeats
  • a transmembrane domain encoded by a large unique exon
  • a distinct cytoplasmic tail specifically interacting with tyrosine kinases
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Pcdh7 protocadherin
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral plasma membrane localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
  • role of PCDH7 in bone metastasis of breast cancer
  • may play important roles in the invasion and metastasis of gastric cancer
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • playing a putative role in cell-cell interactions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
    • PATHWAY
    metabolism
    signaling signal transduction
  • cell-cell signaling
  • potential existence of PCDH7-BIRC5 signaling cascade in the cortical neurons
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • PCDH7 overexpression synergized with EGFR and KRAS to induce MAPK signaling and tumorigenesis in Non-small cell lung cancer (NSCLC)
  • PCDH7 could suppress cell migration and invasion through CDH1 inhibition
  • AR target gene PCDH7 in Androgen-independent prostate cancer (AIPC)
    • cell & other
  • cells expressing in the same protocadherin
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in Androgen-independent prostate cancer (AIPC)
    tumoral     --over  
    in a large number of patients with Castrate resistant prostate cancer (CRPC)
    tumoral     --over  
    frequently in Non-small cell lung cancer (NSCLC) where this event is associated with poor clinical outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can serve as a novel biomarker for diagnostic and prognosis in patients with gastric cancer
  • low PCDH7 expression is a potential prognostic biomarker for primary non-muscle invasive bladder cancer (NMIBC)
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    PCDH7 may be an attractive target in subsets of patients with Castrate resistant prostate cancer (CRPC)
    ANIMAL & CELL MODELS