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FLASH GENE

Symbol

PCDH7

contributors: mct - updated : 21-04-2020

HGNC name	protocadherin 7
HGNC id	8659

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002589 2 splicing 6441 NP_002580 116 1069 - 2017 27821484 PCDH7a NM_032456 1 splicing 4967 NP_115832 116 1072 - 2017 27821484 PCDH7b NM_032457 3 splicing 8749 NP_115833 - 1247 - 2017 27821484 PCDH7c NM_001173523 3 - 8773 NP_001166994 - 1255 - 2017 27821484 PCDH7d

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Hearing/Equilibrium ear       highly Nervous brain       predominantly   brain forebrain cerebral cortex occipital cortex   Homo sapiens   brain forebrain cerebral cortex parietal cortex   Homo sapiens   nerve       highly Urinary kidney       highly

cell lineage
cell lines	in cancer cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	seven extracellular cadherin repeats
	a transmembrane domain encoded by a large unique exon
	a distinct cytoplasmic tail specifically interacting with tyrosine kinases

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Pcdh7 protocadherin

intraspecies

homolog to cadherin

Homologene

FAMILY	cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
	protocadherin subfamily

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane,junction
text	integral plasma membrane localized at the synaptic junction

basic FUNCTION	cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
	role of PCDH7 in bone metastasis of breast cancer
	may play important roles in the invasion and metastasis of gastric cancer

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

development , nervous system

text	playing a putative role in cell-cell interactions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process

PATHWAY

metabolism

signaling

signal transduction

	cell-cell signaling
	potential existence of PCDH7-BIRC5 signaling cascade in the cortical neurons

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	PCDH7 overexpression synergized with EGFR and KRAS to induce MAPK signaling and tumorigenesis in Non-small cell lung cancer (NSCLC)
	PCDH7 could suppress cell migration and invasion through CDH1 inhibition
	AR target gene PCDH7 in Androgen-independent prostate cancer (AIPC)

cell & other

cells expressing in the same protocadherin

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by hypermethylation in Androgen-independent prostate cancer (AIPC) tumoral     --over   in a large number of patients with Castrate resistant prostate cancer (CRPC) tumoral     --over   frequently in Non-small cell lung cancer (NSCLC) where this event is associated with poor clinical outcome

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	can serve as a novel biomarker for diagnostic and prognosis in patients with gastric cancer
	low PCDH7 expression is a potential prognostic biomarker for primary non-muscle invasive bladder cancer (NMIBC)
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate PCDH7 may be an attractive target in subsets of patients with Castrate resistant prostate cancer (CRPC)

ANIMAL & CELL MODELS