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FLASH GENE
Symbol GBAS contributors: mct - updated : 18-05-2011
HGNC name glioblastoma amplified sequence
HGNC id 4179
Location 7p11.2      Physical location : 56.032.295 - 56.067.871
Synonym name nipsnap homolog 2
Synonym symbol(s) NIPSNAP2
DNA
TYPE functioning gene
STRUCTURE 35.57 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D7S506 - EGFR ,GBAS - D7S2429 ] - cen
Authors Wang (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1975 33.6 286 - 2010 20888800
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly Homo sapiens
Digestivemouthtongue    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
Muscularstriatumcardiac   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a transmembrane domain
  • two tyrosine phosphorylation sites
  • a NIPSNAP domain
  • HOMOLOGY
    interspecies ortholog to murine Gbas
    homolog to Drosophila Nipsnap
    homolog to C.elegans K02D10.1b
    intraspecies homolog to highly homologous to NIPSNAP1
    Homologene
    FAMILY
  • NIPSNAP family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • involved in vesicular transport
  • acting as a substrate for tyrosine kinases
  • play a potential role in the process of energy generation by oxidative phosphorylation
  • involved in oxidative phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    with EGFR in glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS