Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KLRC4

contributors: - updated : 04-01-2006

HGNC name	killer cell lectin-like receptor subfamily C, member 4
HGNC id	6377

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracytoplasmic carbohydrate recognition domain homologous with the C type lectin family member, group V
	an extracellular domain (62 residues) that is truncated relative to other NKG2 molecules
	both a positively charged residue in its transmembrane region
	an intracellular ITIM-like sequence

HOMOLOGY

Homologene

FAMILY

natural killer cell lectin-like receptor subfamily C

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II integral membrane protein

basic FUNCTION	triggering target cell lysis by NK cells
	may play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells
	receptor component with an as yet unidentified partner(s), may be regulating cell activation through competition for TYROBP with other receptors, such as NKG2C and -E/H, or may be simply vestigial gene product

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	cellular defense receptor

PATHWAY

metabolism

signaling

a component	constituent with HCST of an activating complex receptor for MICA
	forming an heterodimer with the CD94 receptor (KLRD1)

INTERACTION

DNA

RNA

small molecule

protein

associating with TYROBP, thereby providing activation signaling potential

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS