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Symbol TM7SF2 contributors: mct - updated : 20-06-2007
HGNC name transmembrane 7 superfamily member 2
HGNC id 11863
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM)
  • a sterol reductase-like carboxyl terminal domain
    • HOMOLOGY
    Homologene
    FAMILY seven pass transmembrane superfamily
    k1G protein coupled receptor superfamily in the MEN1 region,LBR superfamily
    CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text located in the endoplasmic reticulum and continuous outer nuclear membrane
    basic FUNCTION
  • involved in the conversion of lanosterol to cholesterol
  • playing a primary role in cholesterol biosynthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    sterol biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS