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FLASH GENE
Symbol QARS contributors: mct - updated : 18-04-2014
HGNC name glutaminyl-tRNA synthetase
HGNC id 9751
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • N-terminal domain of QARS is suggested to interact with arginyl-tRNA synthetase
    • HOMOLOGY
    interspecies homolog to C.elegans y41e3.4
    Homologene
    FAMILY
  • class 1 aminoacyl tRNA synthetase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • endogenous QARS was mainly distributed in the cytoplasm and showed a similar localization pattern to an endoplasmic reticulum (ER) protein, but not a Golgi protein
    • basic FUNCTION
  • is required for the dendritic and axonal terminal arborization during development
  • important role of QARS during brain development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP3K5 (inhibiting its activity)
  • have glutamine-dependent antiapoptotic functions through binding to ASK1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCH2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS