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FLASH GENE

Symbol

QARS

contributors: mct - updated : 18-04-2014

HGNC name	glutaminyl-tRNA synthetase
HGNC id	9751

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001272073 24 - 2810 NP_001259002 - 764 - Ko (2001) NM_005051 24 - 2843 NP_005042 88 775 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Lymphoid/Immune spleen       highly   thymus       highly Nervous brain forebrain cerebral cortex   highly Homo sapiens Fetal Urinary kidney       highly

cell lineage
cell lines	tumor cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains

N-terminal domain of QARS is suggested to interact with arginyl-tRNA synthetase

HOMOLOGY

interspecies

homolog to C.elegans y41e3.4

Homologene

FAMILY

class 1 aminoacyl tRNA synthetase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
text	endogenous QARS was mainly distributed in the cytoplasm and showed a similar localization pattern to an endoplasmic reticulum (ER) protein, but not a Golgi protein

basic FUNCTION	is required for the dendritic and axonal terminal arborization during development
	important role of QARS during brain development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with MAP3K5 (inhibiting its activity)
	have glutamine-dependent antiapoptotic functions through binding to ASK1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MCCH2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS