Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

EPHB4

contributors: mct - updated : 27-01-2016

HGNC name	EPH receptor B4
HGNC id	3395

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   expressed in ovarian cancers and significantly associated with advanced stage of disease and the presence of ascite tumoral     --over   in a variety of different epithelial cancers including prostate where it has been shown to be involved in survival, migration and angiogenesis tumoral     --over   in transitional cell carcinoma of the bladder tumoral     --over   in papillary thyroid carcinoma cell lines

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer urinary   therapeutic compounds targeting EPHB4 have potential for diagnosing and treating transitional cell carcinoma of the bladder cancer reproductive ovary inhibition of EPHB4 may hence have prognostic and therapeutic utility in ovarian carcinoma cancer endocrine thyroid might be a potential therapeutic target in papillary thyroid carcinoma

ANIMAL & CELL MODELS

deletions of the gene reveal its essential roles for conduit vessel development in mice, suggesting similar functions during human vascular development and deregulation in vascular malformations