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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

IL17RA

contributors: npt/mct - updated : 13-09-2017

HGNC name	interleukin 17 receptor A
HGNC id	5985

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD51

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer tissues compared with adjacent normal tissues tumoral     --over   in the invasive group of pituitary adenomas (pMID: 21279695)

Susceptibility

to ankylosing spondylitis (AS), severe form

Variant & Polymorphism	s4819554 minor allele G in the promoter of the IL17RA gene was associated with AS, severe form

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon IL17A and IL17RA are therapeutic targets in colorectal cancer

ANIMAL & CELL MODELS

in the setting of influenza infection, IL17ra(-/-) mice showed significantly reduced levels of oxidized phospholipids, which have previously been shown to be an important mediator in several models of acute lung injury, including influenza infection