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FLASH GENE

Symbol

IL17RA

contributors: npt/mct - updated : 13-09-2017

HGNC name	interleukin 17 receptor A
HGNC id	5985

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	293 AA extracellular domain
	seven potential N-linked glycosylation sites
	conserved IL17R region, a SEFIR domain, lacking certain elements found in prototypical TIR domains, potentially explaining why they do not engage TIR-containing adaptors (Gaffen 2009), and an extended SEFIR domain is required for IL17RA-mediated signal transduction
	TILL domain seems to be unique to IL17RA, perhaps explaining why IL17RA functions as a common subunit shared by several receptors in the family (Gaffen 2009)
	525 AA cytoplasmic tail

conjugated

GlycoP

mono polymer

trimer

HOMOLOGY

interspecies

homolog to murine Il17r

Homologene

FAMILY

IL17 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	type 1 membrane protein

basic FUNCTION	involved in IL17-induced signaling
	with IL17A, activates genes typical of innate immune cytokines, such as TNFalpha and IL-1beta, despite minimal sequence similarity in their respective receptors (Maitra 2007)
	could be analogous to shared cytokine receptor subunits, such as IL6ST, which is a common signal transducer for molecules of the IL-6 family (Gaffen 2009)
	functional roles for both IL17RB and IL17RA in mediating IL25-induced activities (Rickel 2008)
	role of IL17RA-independent mechanisms in causing autoimmunity and its regulation by TGF-beta
	exhibits signaling properties that are nonredundant with other IL17R family members
	IL17A/IL17RA axis increases aortic arch inflammation during atherogenesis through the induction of aortic chemokines, and the acceleration of neutrophil and monocyte recruitment to this site
	IL17RA signal seems to be protective against infection-induced periapical inflammation and bone destruction via suppression of neutrophil and mononuclear inflammation
	IL17A signaling via IL17RA contributes to the inflammatory host response by inducing recruitment of innate immune cells, but also plays a role in homeostatic neutrophilic granulocyte regulation
	IL17RA appears to be a novel modulator of monocyte phenotype and possible therapeutic target in renal fibrosis
	TLR signaling can directly stimulate the expression of IL17RA, in neuroglial cells, which functionally respond to IL17A by secreting chemokines, accelerating CD4 cell migration, and contributing to the pathogenesis of encephalomyelitis
	IL17RA signals directly within transformed colonic epithelial cells (enterocytes) to promote early tumor development
	expression of IL17RA plays an important role in gastric cancer progression, migration and prognosis
	protective role for IL17RA signaling in regulation of the skin barrier and maintenance of skin immune homeostasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction with IL25
	can also interact with IL17RD (Gaffen 2009)
	functional roles for both IL17RB and IL17RA in mediating IL25-induced activities
	TRAF3 is a receptor proximal negative regulator of IL17 receptor (IL17RA) signaling
	BCL11A is required for expression of I7 receptor (IL7RA) and FLT3 in early hematopoietic progenitor cells
	TAOK1 interacts with IL-17 receptor A (IL17RA) independent of its kinase activity

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IMD51

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer tissues compared with adjacent normal tissues tumoral     --over   in the invasive group of pituitary adenomas (pMID: 21279695)

Susceptibility

to ankylosing spondylitis (AS), severe form

Variant & Polymorphism	s4819554 minor allele G in the promoter of the IL17RA gene was associated with AS, severe form

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon IL17A and IL17RA are therapeutic targets in colorectal cancer

ANIMAL & CELL MODELS

in the setting of influenza infection, IL17ra(-/-) mice showed significantly reduced levels of oxidized phospholipids, which have previously been shown to be an important mediator in several models of acute lung injury, including influenza infection