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FLASH GENE
Symbol CBX2 contributors: mct/npt - updated : 28-01-2012
HGNC name chromobox homolog 2 (Pc class homolog, Drosophila)
HGNC id 1552
Corresponding disease
SRA4 sex reversal XY, CBX2-related
Location 17q25.3      Physical location : 77.751.976 - 77.761.449
Synonym name
  • M33 polycomb-like
  • cell division cycle associated 6
  • modifier 3
  • Synonym symbol(s) CDCA6, M33, MGC10561
    DNA
    TYPE functioning gene
    STRUCTURE 9.39 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4192 - 532 - Garcia (1999)
    - - 1061 - 211 - Garcia (1999)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Reproductivefemale systemuterus  highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a chromatin organization modifier (chromo) domain conserved and chromobox regions were dispensable for chromatin association
  • a AT HOOK DNA-binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila polycomb-like (PcG) chromobox 2
    Homologene
    FAMILY
  • polycomb group CBX family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the compaction of chromatin
  • required to maintain the transcriptionally repressive state of many genes, including hox genes, throughout development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of chromatin-associated class II polycomb repressive complex 1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRA4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS