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FLASH GENE
Symbol MED14 contributors: mlc - updated : 19-12-2007
HGNC name cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
HGNC id 2370
Location Xp11.4-p11.2      Physical location : 40.508.796 - 40.594.804
Synonym name
  • cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)
  • thyroid hormone receptor-associated protein complex component TRAP170
  • transcriptional co-activator CRSP150
  • vitamin D receptor-interacting protein complex component DRIP150
  • Synonym symbol(s) EXLM1, CXorf4, CRSP150, RGR1, CSRP, DRIP150, TRAP170, CRSP2
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE escaping inactivation
    STRUCTURE 87.00 kb     31 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 6768 - 1454 - Lee (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytochrome C family heme binding motif
  • a bipartite nuclear localization signal
  • a domain conserved in S.cerevisiae mediator subunit
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for efficient activation by SP1
  • playing a role in transcriptional coactivation
  • implicated in transcriptional regulation by the glucocorticoid receptor (GR) by acting through its activation functions 1 and 2
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription coactivator
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • subunit of the CRSP (cofactor required for SP1 activation) complex
  • component of other multisubunit complexes e.g. thyroid hormone receptor associated proteins (TRAP)
  • subunit of the large multiprotein complexes TRAP, ARC/DRIP and CRSP
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • RNA polymerase POLII via its carboxy terminal domain
  • activating SP1
  • vitamin D receptor
  • thyroid hormone receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS