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FLASH GENE
Symbol CYP4F3 contributors: mct/npt - updated : 30-06-2010
HGNC name cytochrome P450, family 4, subfamily F, polypeptide 3
HGNC id 2646
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus Cyp4f18 (81.35 pc)
homolog to murine Cyp4f18 (81.15 pc)
Homologene
FAMILY
  • cytochrome P450 subfamily IVF
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • leukotriene beta 4 omega-hydrolase, catalyzing the inactivation of leukotrienne beta 4
  • metabolizing eicosanoid mediators
  • catalysing the inactivation of leukotriene B4 (LTB4), a potent mediator of inflammation responsible for recruitment and activation of neutrophils
  • responsible for the omega-hydroxylation of phytanic acid
  • physiological roles of CYP4F3 and CYP4F12 in eosinophils are different (Kikuta 2007)
  • having an an important role in the resolution of inflammation (Hardwick 2008)
  • may play a role in the development of benzene hematotoxicity and serve as a biomarker of benzene exposure (Zhao 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
    • protein
  • flavoprotein P450 oxidoreductase (POR)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to coeliac disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS