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FLASH GENE

Symbol

CYP4F3

contributors: mct/npt - updated : 30-06-2010

HGNC name	cytochrome P450, family 4, subfamily F, polypeptide 3
HGNC id	2646

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.12      Physical location : 15.751.706 - 15.771.569
Synonym name	cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase)
	leukotriene beta 4 omega-hydrolase
	cytochrome P450-LTB-omega
	leukotriene B4 omega hydroxylase
Synonym symbol(s)	LTB4H, CPF3, CYP4F
EC.number	1.14.13.30

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	19.86 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

alternative promoter

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

located in the CYP4F cluster including CYP4F12 and CYP4F8

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000896 13 initiation site 2988 NP_000887 59.8 520 in neutrophils, monocytes and eosinophils Christmas, Kikuta (1998) variant 2 - splicing initiation site - isoform 2 - 472 adult and fetal liver Christmas (1999) lacking exons 3 and 4 alternate promoters

EXPRESSION

Type	restricted

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine large intestine colon   lowly   intestine small intestine     lowly   liver       lowly   mouth       highly Endocrine pancreas       lowly Lymphoid/Immune thymus       lowly Respiratory respiratory tract larynx     moderately   respiratory tract trachea     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     lowly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Blood/Hematopoietic neutrophil

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

HemoP

mono polymer

monomer

HOMOLOGY

interspecies	homolog to rattus Cyp4f18 (81.35 pc)
	homolog to murine Cyp4f18 (81.15 pc)

Homologene

FAMILY	cytochrome P450 subfamily IVF
	multigenic cytochrome P450 superfamily of mixed-function monooxygenases

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	leukotriene beta 4 omega-hydrolase, catalyzing the inactivation of leukotrienne beta 4
	metabolizing eicosanoid mediators
	catalysing the inactivation of leukotriene B4 (LTB4), a potent mediator of inflammation responsible for recruitment and activation of neutrophils
	responsible for the omega-hydroxylation of phytanic acid
	physiological roles of CYP4F3 and CYP4F12 in eosinophils are different (Kikuta 2007)
	having an an important role in the resolution of inflammation (Hardwick 2008)
	may play a role in the development of benzene hematotoxicity and serve as a biomarker of benzene exposure (Zhao 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

drug , lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH, heme

protein

flavoprotein P450 oxidoreductase (POR)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to coeliac disease

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS