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FLASH GENE

Symbol

ENO1

contributors: mct - updated : 06-12-2011

HGNC name	enolase 1, (alpha)
HGNC id	3350

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme , structural protein , antigen , tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	nuclear form found in almost all the normal tissues while its expression was retained in only 35p100 of the tumors

basic FUNCTION	glycolysis, energy pathway converting 2 phospho-D-glycerate to phosphoenol-pyruvate tau-crystallin with reduced enolase activity
	regulating MYC expression
	has tumour suppressor activity and high level of ENO1 expression has growth inhibitory effects
	activated NOTCH1 receptor and ENO1 cooperate in controlling MYC expression through binding the YY1 response element of the MYC promoter to regulate tumorigenesis
	its structure exhibits distinct surface properties, explaining its various activities, including plasmin(ogen) and DNA binding
	ENO1-mediated promotion of cell transformation and invasion partly via induced CCL20 expression
	glycolytic enzyme that catalyses the formation of phosphoenolpyruvate in the cell cytoplasm
	functions in repressing MYC gene expression and the loss of nuclear ENO1 expression in a large number of invasive ductal breast carcinoma may be a critical step in the development and progression of breast cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	TRAPPC2 interaction with the transcription factors ENO1, PITX1 and SF1
	binds to the P2 c-myc promoter and competes with TATA-box binding protein (TBP) to suppress gene transcription

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   overexpressed in lymphocytic hypophysitis and other autoimmune disease, and in gastric cancer tumoral     --over   prognostic role of ENO1 overexpression in head and neck cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	nuclear ENO1 appears to be a novel and valuable histochemical marker with potential prognostic value in breast cancer
Therapy target
	System Type Disorder Pubmed cancer digestive stomach MBP-1-suppressed COX2 expression plays an important role in the inhibition of growth and progression of gastric cancer

ANIMAL & CELL MODELS