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FLASH GENE

Symbol

ENO1

contributors: mct - updated : 06-12-2011

HGNC name	enolase 1, (alpha)
HGNC id	3350

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.23      Physical location : 8.921.062 - 8.938.780
Synonym name	phosphopyruvate hydratase
	2-phospho-D-glycerate hydro-lyase
	MYC promoter-binding protein 1
	non-neural enolase
Synonym symbol(s)	ENO1L1, PPH, MPB1, MBP1
EC.number	4.2.1.11

DNA

TYPE	functioning gene
STRUCTURE	18.09 kb     12 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
	Binding site   transcription factor
text structure	G+C rich, SP1 binding sites

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001428 12 - 2204 48 433 - 2002 11836316 - - - 1400 37 336 nuclear 2002 11836316 see MBP1 NM_001201483 9 - 2567 - 341 - 2010 20849415 shorter isoform (MBP-1) localized to the nucleus, and functions as a transcriptional repressor of MYC protooncogene by binding to its promoter optimal expression of this gene in tumors may lead to effective clinical therapies for cancers

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye lens         eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	precocious type

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme , structural protein , antigen , tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	nuclear form found in almost all the normal tissues while its expression was retained in only 35p100 of the tumors

basic FUNCTION	glycolysis, energy pathway converting 2 phospho-D-glycerate to phosphoenol-pyruvate tau-crystallin with reduced enolase activity
	regulating MYC expression
	has tumour suppressor activity and high level of ENO1 expression has growth inhibitory effects
	activated NOTCH1 receptor and ENO1 cooperate in controlling MYC expression through binding the YY1 response element of the MYC promoter to regulate tumorigenesis
	its structure exhibits distinct surface properties, explaining its various activities, including plasmin(ogen) and DNA binding
	ENO1-mediated promotion of cell transformation and invasion partly via induced CCL20 expression
	glycolytic enzyme that catalyses the formation of phosphoenolpyruvate in the cell cytoplasm
	functions in repressing MYC gene expression and the loss of nuclear ENO1 expression in a large number of invasive ductal breast carcinoma may be a critical step in the development and progression of breast cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	TRAPPC2 interaction with the transcription factors ENO1, PITX1 and SF1
	binds to the P2 c-myc promoter and competes with TATA-box binding protein (TBP) to suppress gene transcription

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   overexpressed in lymphocytic hypophysitis and other autoimmune disease, and in gastric cancer tumoral     --over   prognostic role of ENO1 overexpression in head and neck cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	nuclear ENO1 appears to be a novel and valuable histochemical marker with potential prognostic value in breast cancer
Therapy target
	System Type Disorder Pubmed cancer digestive stomach MBP-1-suppressed COX2 expression plays an important role in the inhibition of growth and progression of gastric cancer

ANIMAL & CELL MODELS