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FLASH GENE

Symbol

MTRR

contributors: mct - updated : 15-05-2014

HGNC name	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
HGNC id	7473

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MTRRD

Susceptibility

risk factor for neural tube defect, NTD, (combined with low cobalamin) to coronary artery disease (CAD) to migraine with aura

Variant & Polymorphism other	66A>G exert a protective effect on neural tube defect
	MTRR variants may protect against migraine with aura in an older population
	MTRR A66G polymorphism, but not MTR A2756G, is significantly associated with maternal risk for NTDs in Caucasians

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS