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FLASH GENE

Symbol

SLC22A18

contributors: SGE/npt - updated : 24-04-2009

HGNC name	solute carrier family 22, member 18
HGNC id	10964

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BWS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     LOH in lung cancer and in embryonal tumors tumoral     --low   in hepatoblastoma tumoral imprinting       gain of imprinting (GOI) in 18p100 for SLC22A18 and 14p100 for SLC22A18AS, in breast cancer, GOI in hepatocarcinomas

Susceptibility

Wilms'tumor, rhabdomyosarcoma (OMIM268210) and hepatoblastoma

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS