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FLASH GENE
Symbol SLC22A18 contributors: SGE/npt - updated : 24-04-2009
HGNC name solute carrier family 22, member 18
HGNC id 10964
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten transmembrane domains
  • three A-C motifs specific for family I transporters
    • HOMOLOGY
    interspecies ortholog to murine Slc22a1l
    Homologene
    FAMILY
  • solute carrier family 22, organic cation
  • polyspecific transporter/multidrug resistance gene family
    • CATEGORY tumor suppressor , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • polyspecific transporter for organic cation, sodium independent
  • inducing tumor cell growth arrest
  • tumor suppressing subchromosomal transferable for chloroquine and quinidine-related compounds
  • polyspecific transmembrane transporter involved in
    • tetracycline transport
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , excretion
    text
  • embryonic development small molecule transport
    • PATHWAY
    metabolism
    signaling
    a component
  • putative protein constituent of membrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of UBE2E1-RNF167 complex (define a novel ubiquitin-proteasome pathway)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BWS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    LOH in lung cancer and in embryonal tumors
    tumoral     --low  
    in hepatoblastoma
    tumoral imprinting      
    gain of imprinting (GOI) in 18p100 for SLC22A18 and 14p100 for SLC22A18AS, in breast cancer, GOI in hepatocarcinomas
    Susceptibility Wilms'tumor, rhabdomyosarcoma (OMIM268210) and hepatoblastoma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS