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FLASH GENE
Symbol SLC22A2 contributors: mct/pgu - updated : 02-09-2013
HGNC name solute carrier family 22 (organic cation transporter), member 2
HGNC id 10966
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • twelve transmembrane domains (12TM),with cytoplasmic N and C termini
  • one nucleotide (ATP/GTP) binding site motif
  • cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • polyspecific transporter of organic cations, sodium independent, may be mediating the first step in cation reabsorption
  • non-neuronal monoamine transporters that play a key role in the clearance of monoamines from extracellular compartments
  • plays a crucial role in the renal secretion of organic cations
  • drug transporter that is a critical determinant in the uptake and cytotoxicity of various platinum compounds, particularly oxaliplatin
  • SLC47A1 and SLC22A2 are transport systems that may be of importance for the cellular disposition of agmatine and putrescin
  • involved in the transport of endogenous and exogenous organic cations mainly in cells of the kidney and the brain
  • important postsynaptic determinant of aminergic tonus and mood-related behaviors (PMIS: 21769100)
  • involved in transport of many endogenous and exogenous organic cations, mainly in kidney and brain cells
  • plays a decisive role in the renal secretion of creatinine
  • could work as a low-affinity and high-capacity choline transporter at presynaptic terminals in cholinergic neurons in a firing-dependent manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kidney-specific expression of SLC22A2 is regulated by methylation of the proximal promoter region, interfering with the transactivation by USF1
  • coordinate function of SLC47A1 with SLC22A2 likely contributes to the vectorial renal elimination of organic cationic drugs
  • LAPTM4A is an interaction partner of SLC22A2 (LAPTM4A regulates the function of SLC22A2 by influencing its trafficking to/from the cell membrane and processing it via the intracellular sorting machinery)
  • DDAH1 and L-arginine are substrates of human SLC7A2, SLC22A2, SLC47A1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    potential pharmacological target for mood disorders therapy
    ANIMAL & CELL MODELS