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FLASH GENE

Symbol

SLC22A2

contributors: mct/pgu - updated : 02-09-2013

HGNC name	solute carrier family 22 (organic cation transporter), member 2
HGNC id	10966

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q25.3      Physical location : 160.637.793 - 160.679.963
Synonym name	organic cation transporter (OCT2)
	organic cation transporter member 2
Synonym symbol(s)	OCT2, MGC32628

DNA

TYPE	functioning gene
STRUCTURE	42.17 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	promoter with binding sites for specific transcription factors
	regulatory polymorphism affecting the promoter activity in kidney

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003058 12 splicing 2512 NP_003049 62.6 555 kidney 2002 12089365 also called OCT2-B

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus     Homo sapiens   spinal cord anterior horn       Homo sapiens Urinary kidney       specific Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory renal tubular epithelium     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous cholinergic neuron Homo sapiens Nervous neuron Homo sapiens Urinary epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	twelve transmembrane domains (12TM),with cytoplasmic N and C termini
	one nucleotide (ATP/GTP) binding site motif
	cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization

HOMOLOGY

Homologene

FAMILY	major facilitator superfamily
	organic cation transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	polyspecific transporter of organic cations, sodium independent, may be mediating the first step in cation reabsorption
	non-neuronal monoamine transporters that play a key role in the clearance of monoamines from extracellular compartments
	plays a crucial role in the renal secretion of organic cations
	drug transporter that is a critical determinant in the uptake and cytotoxicity of various platinum compounds, particularly oxaliplatin
	SLC47A1 and SLC22A2 are transport systems that may be of importance for the cellular disposition of agmatine and putrescin
	involved in the transport of endogenous and exogenous organic cations mainly in cells of the kidney and the brain
	important postsynaptic determinant of aminergic tonus and mood-related behaviors (PMIS: 21769100)
	involved in transport of many endogenous and exogenous organic cations, mainly in kidney and brain cells
	plays a decisive role in the renal secretion of creatinine
	could work as a low-affinity and high-capacity choline transporter at presynaptic terminals in cholinergic neurons in a firing-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

facilitated diffusion transport

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	kidney-specific expression of SLC22A2 is regulated by methylation of the proximal promoter region, interfering with the transactivation by USF1
	coordinate function of SLC47A1 with SLC22A2 likely contributes to the vectorial renal elimination of organic cationic drugs
	LAPTM4A is an interaction partner of SLC22A2 (LAPTM4A regulates the function of SLC22A2 by influencing its trafficking to/from the cell membrane and processing it via the intracellular sorting machinery)
	DDAH1 and L-arginine are substrates of human SLC7A2, SLC22A2, SLC47A1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry     potential pharmacological target for mood disorders therapy

ANIMAL & CELL MODELS