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FLASH GENE

Symbol

DRG2

contributors: mct - updated : 24-10-2014

HGNC name	developmentally regulated GTP binding protein 2
HGNC id	3030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	20.01 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see SMCR (phenotype)

regionally located

within the Smith-Magenis critical region

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed DRG2 13 - 1888 40.6 364 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       lowly   thymus       lowly Cardiovascular heart       highly Digestive intestine large intestine colon   lowly   intestine small intestine     lowly Respiratory lung       lowly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective         Lymphoid         Muscular striatum cardiac     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol   digestive Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five G1-G5 motifs of the GTP binding proteins
	TGS domain

HOMOLOGY

interspecies

homolog to murine Drg2

intraspecies

homolog to DRG1

Homologene

FAMILY

GTP1/OBG family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	playing a role in cell proliferation, differentation and death
	role of DRG2 in hepatocellular carcinoma cells apoptosis and the post-translational regulation of DRG2

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

was a substrate of a SKP1-CUL1-F-box E3 ligase complex and inhibition the function of Cullin1 prevented the degradation of DRG2 during apoptosis

cell & other

REGULATION

Other	developmentally regulated
	in response to chemotherapeutic stimuli, the DRG2 protein was rapidly degraded by the proteasome system

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis in human T cells (

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     could be a promising target for future cancer therapy strategies

ANIMAL & CELL MODELS