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FLASH GENE
Symbol DRG2 contributors: mct - updated : 24-10-2014
HGNC name developmentally regulated GTP binding protein 2
HGNC id 3030
Location 17p11.2      Physical location : 17.991.282 - 18.011.292
Synonym symbol(s) DRG-2
DNA
TYPE functioning gene
STRUCTURE 20.01 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see SMCR (phenotype)
regionally located within the Smith-Magenis critical region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1888 40.6 364 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
 thymus   lowly
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon lowly
 intestinesmall intestine  lowly
Respiratorylung   lowly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connective    
Lymphoid    
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five G1-G5 motifs of the GTP binding proteins
  • TGS domain
    • HOMOLOGY
    interspecies homolog to murine Drg2
    intraspecies homolog to DRG1
    Homologene
    FAMILY
  • GTP1/OBG family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in cell proliferation, differentation and death
  • role of DRG2 in hepatocellular carcinoma cells apoptosis and the post-translational regulation of DRG2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • was a substrate of a SKP1-CUL1-F-box E3 ligase complex and inhibition the function of Cullin1 prevented the degradation of DRG2 during apoptosis
    • cell & other
    REGULATION
    Other developmentally regulated
    in response to chemotherapeutic stimuli, the DRG2 protein was rapidly degraded by the proteasome system
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis in human T cells (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    could be a promising target for future cancer therapy strategies
    ANIMAL & CELL MODELS