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FLASH GENE
Symbol SCML1 contributors: mct - updated : 18-07-2008
HGNC name sex comb on midleg-like 1 (Drosophila)
HGNC id 10580
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas    
Hearing/Equilibriumear   highly
Reproductivemale systemtestis  highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver (highly)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two domains of homology with Drosophila transcriptional repressors of the polycomb PcG genes
  • SAM (sterile alpha motif) domain
    • HOMOLOGY
    interspecies homolog to Drosophila sex comb on midleg-like 1(member of polycomb group (PcG))
    homolog to Drosophila desat 1
    homolog to C.elegans Fat-7
    intraspecies homolog to SCML2
    Homologene
    FAMILY
  • SCM family
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in transcriptional repression of HOX genes
  • likely plays a role in testis development and spermatogenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS