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FLASH GENE

Symbol

SCML1

contributors: mct - updated : 18-07-2008

HGNC name	sex comb on midleg-like 1 (Drosophila)
HGNC id	10580

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	alternatively spliced transcripts (Van de Vosse), transcribed from telomere to centromere

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 3 - - 2693 23 208 - Ross(2005) variant 4 - - 2690 23 208 - Ross(2005) variant 1 - - 2923 - 329 - Ross(2005) variant 2 - - 2842 - 302 - Ross(2005)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Endocrine pancreas         Hearing/Equilibrium ear       highly Reproductive male system testis     highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver (highly)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two domains of homology with Drosophila transcriptional repressors of the polycomb PcG genes
	SAM (sterile alpha motif) domain

HOMOLOGY

interspecies	homolog to Drosophila sex comb on midleg-like 1(member of polycomb group (PcG))
	homolog to Drosophila desat 1
	homolog to C.elegans Fat-7

intraspecies

homolog to SCML2

Homologene

FAMILY

SCM family

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in transcriptional repression of HOX genes
	likely plays a role in testis development and spermatogenesis

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	embryogenesis and morphogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS