Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RAD51D

contributors: mct - updated : 08-09-2016

HGNC name	RAD51-like 3 (S. cerevisiae)
HGNC id	9823

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       mutations are more likely to be found in families with two or more ovarian cancers, or in probands with first-degree relatives with ovarian cancer tumoral germinal mutation       germinal deleterious variants in the RAD51 paralogs to breast and ovarian cancers

Susceptibility

to ovarian cancer

Variant & Polymorphism other	RAD51D mutations confer a sixfold increased risk of ovarian cancer

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary cells deficient in RAD51D are sensitive to treatment with a PARP inhibitor, suggesting a possible therapeutic approach for cancers arising in RAD51D mutation carriers

ANIMAL & CELL MODELS