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FLASH GENE

Symbol

RAD51D

contributors: mct - updated : 08-09-2016

HGNC name	RAD51-like 3 (S. cerevisiae)
HGNC id	9823

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q12      Physical location : -
Synonym name	DNA repair protein RAD51 homolog 4
Synonym symbol(s)	TRAD, R51H3, HsTRAD, RAD51L3, BROVCA4

DNA

TYPE	functioning gene
STRUCTURE	20.08 kb     9 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

Map	cen - D17S798 - D17S2139 - RAD51C - D17S822E - D17S1983 - qter
Authors	Pittman (98)

RNA

TRANSCRIPTS	type	messenger

text	two alternatively spliced isoforms, one truncated, one lacking the nucleotide binding motif (Pittman)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_133629 7 - 2082 NP_598332 - 216 - 2004 1510949 V4 or TRAD-D3 lacks a 112 AAs internal segment NM_002878 10 - 2418 NP_002869 - 328 - 2004 1510949 NM_001142571 10 - 2478 NP_001136043 - 348 - 2004 1510949

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Reproductive female system uterus cervix   highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal domain (AAs 1-83), which consists of four short helices flanked by long N- and C-terminal tails, is required for the ssDNA-specific binding function of human Rad51D
	a two ATP binding domains

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae RAD51, D

intraspecies

paralog to RAD51

Homologene

FAMILY

RAD51 gene family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome,telomere
text	to the telomere of the meiotic and somatic cells

basic FUNCTION	likely involved in double strand break repair, recombination and telomere maintenance
	required for homologous recombination and disruption of Holliday junctions with bloom syndrome protein (BLM)
	RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
	RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair
	RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 sequentially orchestrate clinically relevant transactions at replication forks, cooperatively promoting fork remodeling and restart

CELLULAR PROCESS

nucleotide, repair, recombination

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

pathway in cells for the repair of severe DNA damage such as double-strand breaks

a component

member of the BCDX2 protein complex—comprising RAD51B, RAD51C, RAD51D, and XRCC2—which is thought to have several functions in HR, including stabilization of RAD51 nucleoprotein filaments

INTERACTION

DNA

RNA

small molecule

protein	XRCC2 (protection against DNA damaging)
	HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       mutations are more likely to be found in families with two or more ovarian cancers, or in probands with first-degree relatives with ovarian cancer tumoral germinal mutation       germinal deleterious variants in the RAD51 paralogs to breast and ovarian cancers

Susceptibility

to ovarian cancer

Variant & Polymorphism other	RAD51D mutations confer a sixfold increased risk of ovarian cancer

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary cells deficient in RAD51D are sensitive to treatment with a PARP inhibitor, suggesting a possible therapeutic approach for cancers arising in RAD51D mutation carriers

ANIMAL & CELL MODELS