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FLASH GENE
Symbol EEF2 contributors: mct - updated : 26-08-2014
HGNC name eukaryotic translation elongation factor 2
HGNC id 3214
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to TM6SF2
Homologene
FAMILY GTP-binding elongation factor family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic,ribosome
intracellular,nucleus
text
  • polyribosome
    • basic FUNCTION
  • GTP-dependent translocation of the nascent protein
  • is a biochemical sensor that couples miniature synaptic events to local translational suppression in neuronal dendrites
  • intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor, EEF2
  • EEF2 phosphorylation state localized to the growth cone regulates potentially neurite outgrowth
  • EEF2 and RPS6KB1 signaling pathways control protein synthesis and are inhibited during myocardial ischemia
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • EEF2K/EEF2 pathway is a key biochemical sensor that couple neuronal activity to spine plasticity, by controlling the dendritic translation of BDNF
    • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • inactivation of EEF2K by CDK1 may serve to keep EEF2 active during mitosis (where calcium levels rise) and thereby permit protein synthesis to proceed in mitotic cells
  • TRPM7 via its kinase mediates enhanced Thr56 phosphorylation of EEF2
  • EIF5A is closely related to EEF2 function during translation elongation
  • PRKAA2 controls cardiac RPS6KB1 under normoxia and regulates EEF2 but not the MTOR-RPS6KB1 pathway during ischemia
  • substrate of CSK and could locate in the nucleus
  • upon activation, EEF2K phosphorylates and thereby inhibits EEF2, resulting in a dramatic reduction of mRNA translation
    • cell & other
    REGULATION
    Phosphorylated by CSK and CSK-mediated phosphorylation of EEF2 has no effect on its cytoplasmic function in regulating protein translation
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA26
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric and colorectal cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS