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FLASH GENE
Symbol MT1F contributors: mct - updated : 22-10-2015
HGNC name metallothionein 1F (functional)
HGNC id 7398
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.36 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see MT1@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 498 - 44 - 2013 23064051
3 - 456 - 61 - 2013 23064051
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory , storage , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • inhibited function of MT1F in cancer growth
  • is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by LOH in colon cancer tissue
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    heavy metal ions
    protein
    cell & other
    REGULATION
    induced by heavy metal ions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    downregulated in colon cancer tissue
    constitutional     --low  
    significantly down-regulated in proliferating keloid fibroblast (KF)
    tumoral     --low  
    in the liver cancer tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • levels of MT1F and MT2A mRNA could be considered as new markers of poor prognosis of non-small cell lung cancer patients
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may have an important role in gene therapy of hepatocellular carcinoma
    ANIMAL & CELL MODELS