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FLASH GENE

Symbol

RAD51C

contributors: mct/pgu - updated : 10-07-2019

HGNC name	RAD51 homolog C (S. cerevisiae)
HGNC id	9820

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FANCO

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over gain of function in breast cancer (in progression) constitutional     --low   results in a dramatic decrease in mtDNA copy number as well as the complete suppression of a characteristic oxidative stress-induced copy number increase tumoral germinal mutation     loss of function in patients with primary ovarian, fallopian tube, or peritoneal cancers tumoral germinal mutation       in breast and/or ovarian cancer families tumoral germinal mutation       germinal deleterious variants in the RAD51 paralogs to breast and ovarian cancers

Susceptibility

to breast and ovarian cancer

Variant & Polymorphism other	six monoallelic pathogenic mutations in RAD51C confer an increased risk for breast and ovarian cancer
	relative risk of ovarian cancer for RAD51C mutation carriers was augmented

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS