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Symbol RAD51C contributors: mct/pgu - updated : 10-07-2014
HGNC name RAD51 homolog C (S. cerevisiae)
HGNC id 9820
Corresponding disease
FANCO Fanconi anemia, complementation group O
Location 17q22      Physical location : 56.769.962 - 56.811.690
Synonym name
  • DNA repair protein RAD51 homolog 3
  • yeast RAD51 homolog 3
  • RAD51-like protein 2
  • Synonym symbol(s) RECA, RAD51L2, MGC104277, R51H3, BROVCA3, FANCO
    TYPE functioning gene
    STRUCTURE 41.73 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MRPS23 17q22-q23 mitochondrial ribosomal protein S23 C14orf34 14q23.2 chromosome 14 open reading frame 34 ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2 OR4D1 17q24.2 olfactory receptor, family 4, subfamily D, member 1 HSHPX5 17q23.2 HPX-5 LOC124538 17q23.2 similar to Olfactory receptor 4D2 EPX 17q24-q25 eosinophil peroxidase FLJ20345 17q23.2 hypothetical protein FLJ20345 LPO 17q23.1 lactoperoxidase MPO 17q22-q23.1 myeloperoxidase BZRAP1 17q22-q23 benzodiazapine receptor (peripheral) associated protein 1 SUPT4H1 17q21-q23 suppressor of Ty 4 homolog 1 (S. cerevisiae) FLJ20315 17q23.2 hypothetical protein FLJ20315 FLJ40311 17q23.2 hypothetical protein FLJ40311 MTMR4 1721.1-q23 myotubularin related protein 4 PNUTL2 17q22-q23 peanut-like 2 (Drosophila) FLJ40121 17q23.2 hypothetical protein FLJ40121 TEX14 17q22-q23 testis expressed sequence 14 RAD51C 17q22-q23 RAD51 homolog C (S. cerevisiae) PPM1E 17q23.2 protein phosphatase 1E (PP2C domain containing) TRIM37 17q22-q23 tripartite motif-containing 37 LOC348235 17q23.2 hypothetical protein LOC348235 FLJ11029 17q23.2 hypothetical protein FLJ11029 FLJ10587 17q23.2 hypothetical protein FLJ10587 FLJ37451 17q23.2 hypothetical protein FLJ37451 LOC388403 17 similar to Yippee-like protein 2 (DiGeorge syndrome-related protein FKSG4)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 1295 - 376 - 2007 17114795
    also called RAD51C-isoform 1
    2 splicing 607 - 135 - 2007 17114795
    also called RAD51C-isoform 2
    - splicing 1130 - 134 - 1998 9469824
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineparathyroid   highly
    Reproductivefemale systembreastmammary gland highly
     male systemprostate   
    Skin/Tegumentskin   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    at STAGE
  • a nuclear localization signal (NLS)
  • two ATP binding domains
    interspecies homolog to yeast S.cerevisiae Rad51,3
    intraspecies paralog to RAD51
  • RECA family
  • RAD51 subfamily
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • involved in mitosis and meiotic recombination events
  • required for holliday junction processing in recombination process and for gene conversion
  • important role in maintaining correct centrosome numbers and the complexes including RAD51C and XRCC2 or XRCC3 may be of importance in maintaining correct centrosome numbers in mitosis
  • might be important in preventing aneuploidy, suggesting that it could be a potential tumour suppressor
  • adequate expression of RAD51C in cells is essential for maintaining genomic stability and sister chromatid cohesion to prevent malignant transformation
  • functions as TP53-dependent tumor suppressor gene
  • first moderate-to-high risk susceptibility gene for ovarian cancer
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
  • rare breast and ovarian cancer susceptibility gene
  • plays a vital role in the homologous recombination-mediated repair of DNA lesions associated with replication
  • critical role of RAD51C in the Fanconi anemia pathway of interstrand cross-link repair and as a tumor suppressor
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair
  • RAD51B and RAD51C act early in homologous recombination
  • CELLULAR PROCESS cell cycle, division
    pathway in cells for the repair of severe DNA damage such as double-strand breaks
    a component
  • forms a complex that includes either XRCC2 or XRCC3
  • member of the BCDX2 protein complex—comprising RAD51B, RAD51C, RAD51D, and XRCC2—which is thought to have several functions in HR, including stabilization of RAD51 nucleoprotein filaments
    small molecule
  • RAD51B and XRCC3
  • BRCA1 and BRCA2
  • HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR
  • cell & other
    corresponding disease(s) FANCO
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over gain of function
    in breast cancer (in progression)
    constitutional     --low  
    results in a dramatic decrease in mtDNA copy number as well as the complete suppression of a characteristic oxidative stress-induced copy number increase
    tumoral germinal mutation     loss of function
    in patients with primary ovarian, fallopian tube, or peritoneal cancers
    tumoral germinal mutation      
    in breast and/or ovarian cancer families
  • to breast and ovarian cancer
  • Variant & Polymorphism other
  • six monoallelic pathogenic mutations in RAD51C confer an increased risk for breast and ovarian cancer
  • relative risk of ovarian cancer for RAD51C mutation carriers was augmented
  • Candidate gene
    Therapy target