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FLASH GENE

Symbol

RAD51B

contributors: mct/pgu - updated : 28-03-2020

HGNC name	RAD51-like 1 (S. cerevisiae)
HGNC id	9822

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       RAD51L1/HMGIC fusion in uterine leiomyoma in t(12;14)(q15;q24) tumoral   translocation     translocation t(6;14) (p21.3-q24) in pulmonary chondroid hamartoma constitutional     --low   haploinsufficiency leads to centrosome fragmentation and aneuploidy tumoral germinal mutation       germinal deleterious variants in the RAD51 paralogs to breast and ovarian cancers

Susceptibility

to male breast cancer

Variant & Polymorphism SNP	SNP associated with breast cancer
	a SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS