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FLASH GENE

Symbol

CHD3

contributors: mct - updated : 15-05-2017

HGNC name	chromodomain helicase DNA binding protein 3
HGNC id	1918

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	anonymous DNA segment
SPECIAL FEATURE	arranged in tandem
STRUCTURE	27.95 kb     39 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - CHD3 - D17S786 - cen
Authors	Woodage (97)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001005271 40 - 7372 NP_001005271 - 2059 - 2007 17626165 NM_005852 39 - 7241 NP_005843 - 1966 - 2007 17626165 NM_001005273 40 - 7343 NP_001005273 - 2000 - 2007 17626165

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Lymphoid/Immune lymph node       highly   thymus       highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a paired PHD type (C4-H-C3) zinc finger motif
	two DNA binding chromodomains toward the N terminal
	a central helicase ATPase related SNF2 domain
	a region with similarity to the Myb-DNA binding domain

HOMOLOGY

interspecies

homolog to C.elegans t14g8.1

Homologene

FAMILY	member of the ZNF2/RAD54 helicase family
	CHD family

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	regulator transcriptional for multiple genes and regulator of the chromatin structure
	ATP-dependent chromatin remodelers that contribute to repression of developmentally regulated genes
	might play an important role in tooth root development and subsequent cementogenesis
	SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the chromatin remodeling complex

INTERACTION

DNA

RNA

small molecule

protein	interacting with pericentrin (forms complexes with CHD3 and CHD4, but a distinct CHD3-pericentrin complex is required for centrosomal anchoring of pericentrin/gamma-tubulin and for centrosome integrity)
	interact with SERBP1 and HABP4
	PRPF19 interacts with PHD3 to suppress the cell death under hypoxic conditions by limiting the function of PHD3 which leads to caspase activation
	interacting with TRIM28 (TRIM28(Ser824) phosphorylation generates a motif that directly perturbs interactions between CHD3 SUMO-interacting motif and SUMO1, dispersing CHD3 from heterochromatin DSBs and enabling repair)
	SENP1 physically interacts with the chromatin remodeler chromodomain helicase DNA-binding protein 3 (CHD3)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IDDMSF

Susceptibility

dermatomyositis to Chiari I malformation (CM1)

Variant & Polymorphism other	de novo mutations in CHD3 among individuals with CM1

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS