SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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text
| resides in the outer mitochondrial membrane |
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constitutively located within the mitochondrial outer membrane |
basic FUNCTION
| binding the mitochondrial membrane permeability transition pore and promoting apoptosis by accelerating cytochrome c release |
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contributing with BAX to regulation of endoplasmic reticulum and mitochondria calcium, essential gateway for selected apoptotic signal |
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in association with BAX, functions at the ER membrane to activate inositol-requiring enzyme 1 alpha (IRE1alpha) and to provide a physical link between members of the core apoptotic pathway and the unfolded protein response (UPR) |
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is a required factor for long-chain ceramide production in response to pro-apoptotic stress |
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critical role for BAX and BAK1 in early T-cell development |
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with BAX, are required to prevent T-cell malignancy, and for normal T-cell differentiation, regulating early T-cell development at the stage of early T-lineage progenitor cells |
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regulates endoplasmic reticulum membrane permeability to luminal proteins during apoptosis ( |
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participates in the regulation of mitochondrial fusion ( |
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BAX and BAK1 regulate necrosis, suggesting a connection between mitochondrial events that mediate apoptosis and necrosis |
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BAK1 and BAX are two proapoptotic members of the Bcl-2 protein family with overlapping, essential roles in the intrinsic apoptotic pathway |
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critical role for BAK1 and an ancillary role for BAX in safeguarding immunological tolerance and prevention of autoimmune disease |
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BAK1 and BAX are necessary for immunological tolerance of ubiquitous self-antigens |
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BAX and BAK1 mediate the permeabilization of the mitochondrial outer membrane during apoptosis |
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multidomain pro-apoptotic Bcl-2 family proteins BAK1 and BAX are believed to form large oligomeric pores in the mitochondrial outer membrane during apoptosis |
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analogous mechanism for activation and dimerization of BAK1 and BAX in response to certain BH3 peptides |
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oligomerized BAX and BAK1 trigger apoptosis by causing both the permeabilization of the mitochondrial outer membrane and activation OMA1 |
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BAX and BAK1 can permeabilize the outer mitochondrial membrane and commit cells to apoptosis |