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FLASH GENE
Symbol BCL2L2 contributors: mct - updated : 03-12-2014
HGNC name BCL2-like 2
HGNC id 995
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • from the N terminal, three BCL2 homology domains, BH3, BH1, BH2
  • bh4 motif seems to be involved in the anti-apoptotic function
  • a C terminal membrane anchoring segment
    • secondary structure eight alpha helices
    HOMOLOGY
    Homologene
    FAMILY BCL-2 family of anti-apoptotic proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • evidence of BCL2L2 localization in the growth cones of differentiating neuronal cells
    • basic FUNCTION
  • promotes cell survival
  • mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX
  • essential for the regulation of cellular survival, and up-regulated in different human tumors, such as gastric and colorectal carcinomas
  • not only promotes neuronal survival, but also neuronal differentiation
  • is required for the viability of small fiber nociceptive sensory neurons
  • functions of BCL2L2 and BAX are mimicked by other pro-survival and pro-apoptotic members, such as BCL2L1 and BAK, respectively
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • 17beta-estradiol (E2) upregulates expression of antiapoptotic BCL2L2 and downregulates expression of proapoptotic BCL2L11 in an estrogen receptor (ER)-dependent manner
  • BCL2L2 and GRID2 might interact genetically to regulate mitochondria, autophagy, and neuronal function
  • AKT1 may induce anti-apoptotic signals at least in part through the regulation of the amount and activity of BCL2L2
  • upon stress, NEUROD6 promotes colocalization of BCL2L2 with mitochondria and endoplasmic reticulum
  • interacts with BAX and suppresses the CASP6 apoptotic cascade that fosters axonal degeneration
    • cell & other
    REGULATION
    induced by pericytes that induced the antiapoptotic protein BCL2L2 in tumor endothelial cells (ECs)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Bclw(-/-) mice demonstrate an adult-onset progressive decline in thermosensation and a decrease in nociceptor innervation of the epidermis