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FLASH GENE

Symbol

BCL2L2

contributors: mct - updated : 03-12-2014

HGNC name	BCL2-like 2
HGNC id	995

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q11.2      Physical location : 23.776.011 - 23.780.966
Synonym name	apoptosis regulator BCL-W
	protein phosphatase 1, regulatory subunit 51
Synonym symbol(s)	KIAA00271, BCLW, BCL-W, BCL2-L-2, PPP1R51

DNA

TYPE	functioning gene
STRUCTURE	4.99 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001199864 3 - 2130 NP_001186793 - 333 - 2003 12660157 NM_004050 4 - 3521 NP_004041 - 193 - 2003 12660157 NM_001199839 4 - 3576 NP_001186768 - 193 - 2003 12660157

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage	lymphoid and myeloid cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	from the N terminal, three BCL2 homology domains, BH3, BH1, BH2
	bh4 motif seems to be involved in the anti-apoptotic function
	a C terminal membrane anchoring segment

secondary structure

eight alpha helices

HOMOLOGY

Homologene

FAMILY

BCL-2 family of anti-apoptotic proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
text	evidence of BCL2L2 localization in the growth cones of differentiating neuronal cells

basic FUNCTION	promotes cell survival
	mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX
	essential for the regulation of cellular survival, and up-regulated in different human tumors, such as gastric and colorectal carcinomas
	not only promotes neuronal survival, but also neuronal differentiation
	is required for the viability of small fiber nociceptive sensory neurons
	functions of BCL2L2 and BAX are mimicked by other pro-survival and pro-apoptotic members, such as BCL2L1 and BAK, respectively

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	17beta-estradiol (E2) upregulates expression of antiapoptotic BCL2L2 and downregulates expression of proapoptotic BCL2L11 in an estrogen receptor (ER)-dependent manner
	BCL2L2 and GRID2 might interact genetically to regulate mitochondria, autophagy, and neuronal function
	AKT1 may induce anti-apoptotic signals at least in part through the regulation of the amount and activity of BCL2L2
	upon stress, NEUROD6 promotes colocalization of BCL2L2 with mitochondria and endoplasmic reticulum
	interacts with BAX and suppresses the CASP6 apoptotic cascade that fosters axonal degeneration

cell & other

REGULATION

induced by

pericytes that induced the antiapoptotic protein BCL2L2 in tumor endothelial cells (ECs)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Bclw(-/-) mice demonstrate an adult-onset progressive decline in thermosensation and a decrease in nociceptor innervation of the epidermis