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FLASH GENE

Symbol

LAIR2

contributors: mct - updated : 14-03-2012

HGNC name	leukocyte-associated Ig-like receptor 2
HGNC id	6478

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	7.90 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	see FLNKR@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002288 5 - 702 NP_002279 - 152 - 2008 18209062 NM_021270 4 - 651 NP_067154 - 135 - 2008 18209062

EXPRESSION

Rna function	LAIR2 mRNA was found only in the more distal portions of trophoblast anchoring cell columns, adjacent to the invading extravillous trophoblast (EVT)
Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a single Ig-like domain
	a cytoplasmic tail
	a immunoreceptor tyrosine based inhibitory motif (ITIM)

HOMOLOGY

intraspecies

homolog to LAIR1

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	membrane protein type 1

basic FUNCTION	may function as a natural competitor for LAIR1, thereby regulating its inhibitory potential
	prevents binding of LAIR1 to collagens, suggesting that the protein has an immunoregulatory function
	alterations in LAIR2 may play an etiologic role in preeclampsia
	has the capacity to interfere with platelet-collagen interactions mediated by Glycoprotein VI and the VWF/Glycoprotein Ib axis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	LAIR1 and LAIR2 bind several of these collagen-like peptides, with LAIR2 being able to bind more than LAIR1
	binds collagen and can interfere with LAIR1/collagen interactions

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   its levels are increased in synovial fluid of patients with rheumatoid arthritis as compared with osteoarthritis patients constitutional     --low   in the first trimester of pregnancies destined for preeclampsia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS