Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NEURL contributors: mct - updated : 15-07-2015
HGNC name neuralized-like (Drosophila)
HGNC id 7761
Location 10q24.33      Physical location : 105.253.734 - 105.352.308
Synonym name
  • h-neuralized 1
  • RING finger protein 67
  • neuralized-like protein 1A
  • Synonym symbol(s) DNH, NEURL1, RNF67, h-neu, neu, neu-1, NEUR1
    DNA
    TYPE functioning gene
    STRUCTURE 98.57 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map see TSG10B
    regionally located within the malignant astrocytoma region on chromosome 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4315 - 574 - 1998 9519875
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     pancreas   highly
    Nervousbrainhindbraincerebellum highly Homo sapiensFetal
     brainforebrain    Mus musculusAdult
     brainlimbic systemhippocampus   Mus musculus
    Visualeye   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila neuralized
    homolog to murine Neurl (89%)
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • myristoylated at its N terminus, and myristoylation of NEURL targets it to the plasma membrane
  • CPEB3 and NEURL colocalize along the apical dendrites of adult CA1 neurons, in opposition to Synaptophysin
  • basic FUNCTION
  • potentially involved in neurogenesis
  • at the plasma membrane can affect the signaling activity of JAG1 by directly enhancing its ubiquitination and subsequent turnover
  • NEURL-mediated ubiquitination increases AMPAR synthesis and synaptic spine number
  • NEURL and ubiquitin modulate CPEB3-dependent translation of GRIA1 and GRIA2
  • ability of NEURL to ubiquitinate CPEB3 is a limiting factor and facilitates hippocampal synaptic plasticity and hippocampal-dependent memory by modulating CPEB3 translational activity through ubiquitination with consequent induction of an increase of GRIA1 and GRIA2 protein levels and the formation of new spines
  • CAPN2 activated through NMDAR sign
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can function as an E3 ubiquitin ligase to activate monoubiquitination of Jagged1, but not other mammalian Notch ligands
  • NEURL and NEURL2 interact with another Notch ligand, DLL4
  • directly interacts with and monoubiquitinates the cytoplasmic polyadenylation element-binding protein 3 (CPEB3), an RNA-binding protein and translational regulator
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to to Atrial Fibrillation (AF)
    Variant & Polymorphism SNP
  • significant genotypic association was found between NEURL SNP rs6584555 and AF
  • Candidate gene
  • candidate tumor suppressor in medulloblastoma, at least in part through its effects on the NOTCH pathway
  • Marker
    Therapy target
    ANIMAL & CELL MODELS