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FLASH GENE
Symbol AGPAT1 contributors: mct - updated : 29-10-2010
HGNC name 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
HGNC id 324
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transmembrane domain is predicted to separate motif I on the cytosolic side from motifs II-III on the lumenal side, with motif IV near surface of the membrane (motifs II and III are involved in lysophosphatidic acid binding and motifs I and IV are involved in acyl-CoA binding)
  • four conserved motifs (I–IV), whose invariant residues appear to be important for catalysis and/or substrate recognition
    • HOMOLOGY
    Homologene
    FAMILY
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the conversion of lysophosphophatidic acid to phosphatidic acid
  • involved in de novo biosynthesis of glycerolipids, such as phospholipids and triacylglycerol
  • implicated in the development of skeletal muscle, specifically to terminal differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    second step in de novo phospholipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS