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FLASH GENE

Symbol

LEFTY2

contributors: mct/npt - updated : 25-05-2010

HGNC name	left-right determination factor 2
HGNC id	3122

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HTX9

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs constitutional         some types of infertility are associated with a dysregulated expression of the gene in the endometrium

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

lefty 1-/- mutant mice have bilateral expression of Nodal and left isomerism