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FLASH GENE
Symbol TAPBP contributors: mct - updated : 26-03-2014
HGNC name TAP binding protein (tapasin)
HGNC id 11566
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   moderately
Endocrinepancreas   moderately
Lymphoid/Immunelymph node   moderately
Nervousnerve   highly
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland highly
 female systemovary  moderately
 female systemuterus  moderately
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 20 amino acids signal peptide (1.9 kDa)
  • a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum
  • two core domains of different sizes loosely linked by a flexible region
  • an immunoglobuline-like C1-type domain
  • conjugated GlycoP
    isoforms Precursor a 428 amino acids mature peptide (45.6 kDa)
    HOMOLOGY
    interspecies homolog to rattus Tapbp (75.84 pc)
    homolog to murine Tapbp (75.17 pc)
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • member of the MHC class I
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    text type 1 membrane glycoprotein
    basic FUNCTION
  • transporter associated with antigen processing, involved in the assembly and function of multimeric MHC class I-TAP complexes, linking the heavy chain to TAP
  • may be involved in the redox regulation of components during assembly and peptide loading
  • not only required for stabilization of TAP but also for optimization of the spectrum of bound peptides
  • has an intrinsic ability to recruit MHC class I molecules and promote assembly, but also uses generic folding factors to enhance MHC class I recruitment and assembly
  • central role in the assembly of the peptide-loading complex by stabilizing TAP expression, determining peptide selection, and maintaining an appropriate MHC class I redox status
  • TAP1 and TAP-associated glycoprotein (TAPBP) play important roles in regulating MHC class I expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HLA-I, TAP1, TAP2
  • ER-resident peptide-loading complex (PLC) consists of the transporter associated with antigen processing (TAP1 and TAP2), assembled with the auxiliary factors TAPBP and MHC I
  • TAP1, TAP2/TAPBP complex formation is driven by hydrophobic interactions via leucine zipper-like motifs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with E2F1, an essential transcription factor for tapasin
  • truncated actin P binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BLS1C
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer, melanoma, colorectal carcinoma, cervical cancer, small cell and non-small cell lung carcinoma, fibrosarcoma, as well as bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS