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FLASH GENE
Symbol SEMG2 contributors: mct - updated : 05-01-2007
HGNC name semenogelin II
HGNC id 10743
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text located 3' to SEMG1 in a head to tail arrangement
STRUCTURE 3.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemseminal vesicles   
 male systemmale genital tractepididymis  
 male systemprostate   
 male systemmale genital tractvas deferens  
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion semen
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide C terminal non coding nucleotide
    • HOMOLOGY
    interspecies homolog to murine Syp3
    Homologene
    FAMILY semenogelin family
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • formation of a gel matrix entrapping the accessory gland secretion and ejaculated spermatozoa
  • participating in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions
    • and ejaculated spermatozoa
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major constituent protein of seminal fluid
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding semenogelins I and zinc and regulate the activity of prostate-specific antigen (KLK3)
  • cleaved by KLK14
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS