Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | RAG2 | contributors: mct/npt/pgu - updated : 27-01-2010 |
HGNC name | recombination activating gene 2 |
HGNC id | 9832 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 6.32 kb 2 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter | |
Binding site HRE | ||
motif
text structure
| proximal and distal regulatory elements | |
MAPPING | cloned | Y | linked | N | status | confirmed |
regionally located | located 8kb apart from RAG1, convergently oriented 1 |
RNA |
TRANSCRIPTS | type | messenger |
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|
EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
|
cells |
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cell lineage | |
| |
cell lines
fluid/secretion
| |
at STAGE |
cell cycle | cell cycle |
life cycle | G0 |
PROTEIN |
PHYSICAL PROPERTIES | Hydrophobic | |
STRUCTURE |
mono polymer | heteromer , dimer , complex |
HOMOLOGY |
interspecies | ortholog to murine Rag2 |
ortholog to rattus rag2 |
Homologene |
FAMILY |
CATEGORY | immunity/defense , DNA associated |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus,nucleolus | |
text | localized in the epithelial layer and absent in the lamina propria of intestine |
CELLULAR PROCESS | nucleotide, recombination |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
INTERACTION |
DNA | binding |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
inhibited by | activation of Abl and Erk kinases in T cells, leading to the transcriptional inactivation of RAG1 and RAG2 |
ASSOCIATED DISORDERS |
corresponding disease(s) | SCIDO , SCIDBL , CCHIG |
related resource | RAG2base: Mutation registry for autosomal recessive RAG2 immunodeficiency |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
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ANIMAL & CELL MODELS |