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FLASH GENE

Symbol

DRD2

contributors: mct/pgu - updated : 31-08-2016

HGNC name	dopamine receptor D2
HGNC id	3023

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function dysfunction during adolescence impairs neuronal circuits and working memory, and indicate that adolescent interventions to prevent aberrant DRD2 activity protect against cognitive impairment constitutional       loss of function is a critical mechanism mediating cocaine-induced glutamate plasticity in ventral tegmental area (VTA) neurons

Susceptibility

to opium addiction in Iranian population to schizophrenia to suicide to speech disfluency to nicotine dependence (ND) and alcohol dependence (AD)

Variant & Polymorphism SNP , other	may be association of the S311C variant with schizophrenia
	141C ins/del asociated with schizophrenia and alcoholism
	allele A1-A1 increases the risk of opium addiction in Iranian population
	polymorphisms that may be involved in the biological susceptibility to suicide
	C allele at rs6277 is associated with increased susceptibility to speech disfluency
	association of DRD2 and its adjacent gene ankyrin repeat and kinase domain containing 1 (ANKK1) with nicotine dependence (ND) and alcohol dependence (AD)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry     potential impact of future therapeutic strategies that enhance DRD2 signaling in the nucleus accumbens (NAc) tumor     DRD2 and SSTR3 seem to be the most promising targets for pharmacological treatment of pituitary adenomas

ANIMAL & CELL MODELS