protein
| calnexin interactions critically regulate DRD2 |
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NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA |
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functional interaction between TAAR1 and DRD2 |
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expression of ZNF804A results in a statistically significant decrease in transcript levels of PDE4B and DRD2 |
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association of ANKK1/DRD2 implicates the role of nicotine-related pathways and dopamine signaling in language processing, particularly in comprehension and phonological memory |
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CDK5-mediated phosphorylation of S321 inhibits DRD2 function, providing a novel regulatory mechanism for dopamine signaling |
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DRD2, via paraoxonase 2 and SESN2, keeps normal renal redox balance, which contributes to the maintenance of normal blood pressure |
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interactions between DRD2 and GNB5 are not mediated by endogenously expressed RGS7 proteins |
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is a prominent target for drug treatments in disorders where dopamine function is aberrant, such as schizophrenia |
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NCS1 interacts with both the G-protein-coupled receptor (GPCR) DRD2, regulating its internalization and surface expression, and the cognate kinases GRK1 and ADBRK1 |
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ZDHHC3 and ZDHHC8, also interacted with the DRD2 and each of the palmitoyl acyltransferase (PAT) was capable of affecting the palmitoylation status of the DRD2 |
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TSPAN7 negatively affects DRD2-mediated signaling |
Variant & Polymorphism
SNP
, other
| may be association of the S311C variant with schizophrenia |
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141C ins/del asociated with schizophrenia and alcoholism |
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allele A1-A1 increases the risk of opium addiction in Iranian population |
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polymorphisms that may be involved in the biological susceptibility to suicide |
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C allele at rs6277 is associated with increased susceptibility to speech disfluency |
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association of DRD2 and its adjacent gene ankyrin repeat and kinase domain containing 1 (ANKK1) with nicotine dependence (ND) and alcohol dependence (AD) |
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