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FLASH GENE

Symbol

GSTM4

contributors: mct/npt - updated : 13-02-2010

HGNC name	glutathione S-transferase mu 4
HGNC id	4636

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   resulted in an increased sensitivity of Ewing's sarcoma cells to chemotherapeutic agents, suggesting a role for this protein in drug resistance (Luo 2009)

Susceptibility

to lung cancer

Variant & Polymorphism other	T2517C polymorphism in GSTM4 was shown to associate with an increased risk of developing lung cancer (Luo 2009)

Candidate gene
Marker
Therapy target	reduction of GSTM4 levels confer increased sensitivity to some cytotoxic agents in Ewing's sarcoma, and further suggest that inhibition of GSTM4 activity might be used in combination with chemotherapy to increase therapeutic responses in Ewing's sarcoma (Guo 2009)

ANIMAL & CELL MODELS