Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GSTM4 contributors: mct/npt - updated : 13-02-2010
HGNC name glutathione S-transferase mu 4
HGNC id 4636
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to C.elegans r107.7
Homologene
FAMILY
  • GST superfamily
  • Mu family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in proliferation and oncogenic transformation is likely specific to Ewing's sarcoma (Guo 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • critical EWS/FLI target gene in Ewing's sarcoma (directly binds the GSTM4 promoter, and regulates GSTM4 expression through a GGAA-microsatellite in its promoter)(Luo 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    resulted in an increased sensitivity of Ewing's sarcoma cells to chemotherapeutic agents, suggesting a role for this protein in drug resistance (Luo 2009)
    Susceptibility to lung cancer
    Variant & Polymorphism other T2517C polymorphism in GSTM4 was shown to associate with an increased risk of developing lung cancer (Luo 2009)
    Candidate gene
    Marker
    Therapy target reduction of GSTM4 levels confer increased sensitivity to some cytotoxic agents in Ewing's sarcoma, and further suggest that inhibition of GSTM4 activity might be used in combination with chemotherapy to increase therapeutic responses in Ewing's sarcoma (Guo 2009)
    ANIMAL & CELL MODELS