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FLASH GENE
Symbol GSTM2 contributors: mct - updated : 22-12-2021
HGNC name glutathione S-transferase M2 (muscle)
HGNC id 4634
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal half of GSTM2 (GSTM2C) is essential for RYR2 inhibition
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Gstm2
    homolog to C.elegans T28A11.11
    Homologene
    FAMILY
  • GST superfamily
  • mu family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • sarcoplasmic reticulum
    • basic FUNCTION
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • GSTM2-2 is a novel luminal regulator of the RyR channels in the heart (Wei 2008)
  • absence of GSTM1 activity can be compensated for by the overexpression of GSTM2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    detoxification
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ca(2+) release from the sarcoplasmic reticulum through cardiac ryanodine receptors (RYR2) is essential for heart function and is inhibited by the C-terminal domain of glutathione transferase M2-2 (GSTM2-C)
  • GSTM2 inhibiting RYR2, in a manner that indicates a possible therapeutic potential for treatment of arrhythmia in the neonatal heart
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly associated with favorable prognosis in Colon adenocarcinoma (COAD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS