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FLASH GENE

Symbol

GSTM2

contributors: mct - updated : 22-12-2021

HGNC name	glutathione S-transferase M2 (muscle)
HGNC id	4634

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NP_001135840 8 - 1166 NP_000839 25.6 218 - 1991 2034681 NM_001142368 9 - 1443 NP_001135840 22.5 191 - 1991 2034681

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal half of GSTM2 (GSTM2C) is essential for RYR2 inhibition

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to murine Gstm2
	homolog to C.elegans T28A11.11

Homologene

FAMILY	GST superfamily
	mu family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
text	sarcoplasmic reticulum

basic FUNCTION	conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
	GSTM2-2 is a novel luminal regulator of the RyR channels in the heart (Wei 2008)
	absence of GSTM1 activity can be compensated for by the overexpression of GSTM2

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

detoxification

a component

INTERACTION

DNA

RNA

small molecule

protein	Ca(2+) release from the sarcoplasmic reticulum through cardiac ryanodine receptors (RYR2) is essential for heart function and is inhibited by the C-terminal domain of glutathione transferase M2-2 (GSTM2-C)
	GSTM2 inhibiting RYR2, in a manner that indicates a possible therapeutic potential for treatment of arrhythmia in the neonatal heart

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly associated with favorable prognosis in Colon adenocarcinoma (COAD)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS