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FLASH GENE
Symbol SLCO1A2 contributors: mct - updated : 13-01-2020
HGNC name solute carrier organic anion transporter family, member 1A2
HGNC id 10956
Location 12p1.1      Physical location : 21.417.534 - 21.548.371
Synonym name
  • solute carrier family 21 (organic anion transporter), member 3
  • sodium-independent organic anion transporter
  • organic anion-transporting polypeptide 1
    • Synonym symbol(s) OATP1, OATPA, OATP, SLC21A3, OATP-A, OATP1A2
    DNA
    TYPE functioning gene
    STRUCTURE 139.06 kb     16 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • putative nuclear factor-KB (NFKB) binding site ranging from -1845 to -1836 was identified at the proximal promoter region of OATP1A2 coding gene SLCO1A2
    • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 7695 - 670 - 2018 30348897
  • OATP1-A
    • 14 splicing 7231 - 670 - 2018 30348897
    OATP1-B
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
    Nervousbrain   predominantly Homo sapiens
    Reproductivemale systemtestis   
    Urinarykidney     Homo sapiens
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains
  • eight potential glycosylation sites
  • six potential protein kinase C phosphorylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Slc21a7
    Homologene
    FAMILY solute carrier family 21, organic anion
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • basolateral membrane
  • expressed in the luminal membrane of human blood-brain barrier (BBB)
    • basic FUNCTION
  • involved in the transport of thyroid hormones,taurocholic acid and pravastatin (hepatic uptake of the liver-specific hydroxymethyl-glutaryl CoA reductase inhibitor)
  • role in the cellular uptake of All-trans-retinol (atROL), which might be essential to the proper functioning of the canonical visual cycle
  • membrane transporter that mediate the transport of wide ranges of compounds
  • membrane protein that mediate the cellular uptake of drugs and endogenous substances
  • role for AMPK in regulating OATP1A2 protein stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text transepithelial organic anion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • protein kinase C regulates the transport function of OATP1A2 by modulating protein internalization
  • anti-migraine triptans are substrates for SLCO1A2, a transporter expressed at human blood-brain barrier
  • PDZK1 and SLC9A3R1 regulate the transport function of SLCO1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability
  • transports VPA across the blood-brain barrier (BBB), suggesting altered SLCO1A2 expression may contribute to resistance to valproic acid (VPA) in patients with drug-resistant epilepsy
    • cell & other
    REGULATION
    induced by vitamin D(3) at the transcriptional level through the vitamin D receptor (VDR)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to impaired efficacy or enhanced toxicity during treatment with drugs that are substrates for SLCO1A2
    Variant & Polymorphism SNP
  • SNPs in the SLCO1A2 gene may be at risk from impaired efficacy or enhanced toxicity during treatment with drugs that are substrates for SLCO1A2
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS